Tacrolimus by HPLC-MS/MS TACROL

Method(s) Liquid Chromatography-Tandem Mass Spectrometry
Synonym Prograf®, FK506
Specimen Required
Collect

One 3 mL lavender (EDTA) top tube.

Transport

1 mL whole blood at 2-8°C. (Min: 0.25 mL)

Remarks

Specimen should be drawn 12 hours post-dose or just prior to next dose (trough sample).

Stability

Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 2 months

Unacceptable Conditions

Clotted specimens - serum or plasma. Specimens left at room temperature for longer than 24 hours.

Schedule Daily
Billing Code 5011865
CPTCode 80197
Notes

Serial specimen collections should be consistent with respect to the last medication dose, as well as to the time of day, to minimize intra-individual variability.

Preferred Specimen Collection Device(s)
Reference Interval
 
 Therapeutic Range:
Kidney transplant:0-3 months post-transplant: 7.0-20.0 ng/mL
3 months and older: 5.0-15.0 ng/mL
Heart transplant:0-3 months post-transplant: 10.0-20.0 ng/mL
3 months and older: 5.0-15.0 ng/mL
Liver transplant:1-12 months post-transplant: 5-20 ng/mL
Toxic value:Greater than 25 ng/mL
No Appointment Necessary
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12 Patient Service Centers in Central New York.

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