Carbamazepine Epoxide & Total CARBAM
Method(s) | Quantitative Liquid Chromatography-Tandem Mass Spectrometry |
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Specimen Required | |
Collect | One 5 mL plain red top tube, or lavender top (EDTA), or pink (K2EDTA) top tube. |
Transport | 1 mL serum at 2-8°C. (Min. 0.5 mL) |
Remarks | Patient Prep: Obtain trough specimen after steady-state is achieved (3-5 days). Draw within one hour prior to next dose. The epoxide half-life is 6-10 hours. |
Stability | After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month. |
Unacceptable Conditions | Whole blood, separate tubes, light blue (citrate) or yellow (SPS or ACD solution) top tubes. |
Schedule | Mon |
Billing Code | 5011422 |
CPTCode | 80156, 80299 |
Notes | Separate serum or plasma from cells within 2 hours of collection. |
Preferred Specimen Collection Device(s) | |
Reference Interval | |
Carbamazepine -10, 11 Epoxide: Not well established Total Carbamazepine: Therapeutic Range: 4.0-12.0 µg/mL
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