Tacrolimus by Tandem Mass Spectrometry TACR
|Method(s)||Liquid Chromatography-Tandem Mass Spectrometry|
One 3 mL lavender (EDTA) top tube.
3 mL whole blood at 2-8ºC. (Min: 1 mL)
Specimen should be drawn 12 hours post-dose or just prior to next dose (trough sample).
|Stability||Ambient: 24 hours; Refrigerated: 7 days|
Serial specimen collections should be consistent with respect to the last medication dose, as well as to the time of day, to minimize intra-individual variability.
|Preferred Specimen Collection Device(s)|
Method MEIA Kidney / Liver
Initial Period 10 - 15 ng/mL
Recommended target ranges for tacrolimus are largely based on immunoassay values