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Chemistry Tests Susceptible to Biotin Interference

Friday, October 12, 2018

Chemistry tests performed by Laboratory Alliance should not be affected by the biotin (vitamin B7) in over-the-counter multi-vitamins when they are taken as directed.  However, the high doses of biotin, which can be found in various supplements, can lead to erroneous lab results.  Lab methods that utilize reagents comprised of biotin/streptavidin are susceptible to interference from high doses of biotin.  The magnitude of this interference will differ from one susceptible test method to another. 

In an effort to provide our clients with more specific information regarding the effect of biotin supplements on Laboratory Alliance’s test methods, we have compiled the attached tables.  These tables are based on information received from the manufacturers of the diagnostic products used in our laboratory.

It is important for clinicians to ask their patients about their use of biotin supplements and have this information available to discuss with the laboratory in the event lab results are inconsistent with a patient’s clinical presentation. Clinicians should always consider the patient’s clinical presentation when interpreting lab results, and notify the laboratory when interfering substances are suspected.   

Tests potentially affected for patients taking OTC biotin supplements (supplements that
produce mild to moderate elevations of biotin as compared to typical physiologic levels)

Assay*

Platform*

Falsely elevated by biotin

Falsely decreased by biotin

Hepatitis A Total Ab

Siemens Centaur XPT

X

 

Hepatitis B core IgM

Siemens Centaur XPT

 

X

Cat Dander Epithelium Allergen

Siemens Immulite 2000XPi

 

X

CKMB

Siemens Vista

 

X

DHEAS

Siemens Centaur XPT

X

 

Estradiol

Siemens Vista

X

 

Folate

Siemens Vista

X

 

Free T3

Siemens Vista

X

 

Free T4

Siemens Vista

X

 

HBsAg

Siemens Centaur XPT

 

X

Latex Allergen

Siemens Immulite 2000XPi

 

X

NT-proBNP

Siemens Vista

 

X

Progesterone

Siemens Vista

X

 

SHBG

Siemens Centaur XPT

 

X

Testosterone, Total

Siemens Centaur XPT

X

 

Thyroglobulin

Siemens Immulite 2000XPi

 

X

Troponin I

Siemens Vista

 

X

TSH

Siemens Vista

 

X

Vitamin B12

Siemens Vista

X

 

Wheat Allergen

Siemens Immulite 2000XPi

 

X

 

Tests potentially affected for patients taking prescription or mega-doses of biotin (supplements
that 
produce marked elevations of biotin as compared to typical physiologic levels)

Assay*

Platform*

Falsely elevated by biotin

Falsely decreased by biotin

Hepatitis A IgM

Siemens Centaur XPT

 

X

Digoxin

Siemens Vista

X

 

Ferritin

Siemens Vista

 

X

FSH

Siemens Vista

 

X

LH

Siemens Vista

 

X

Prolactin

Siemens Vista

 

X

 Note:  * Assays & platforms in use at Laboratory Alliance as of September 2018

10/10/18 RFH/jar

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